This is part of a recurring series examining landmark articles in Emergency Medicine, in the style of ALiEM’s 52 Articles.
Discussing: The Acute Respiratory Distress Syndrome Network. “Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome” N Eng J Med, May 2000; 342(18): 1301-08
This landmark study was stopped early! It determined that in patients with acute respiratory distress syndrome (ARDS) who are treated with lower tidal volumes than those treated with traditional volumes:
- Mortality is decreased by 31.0% vs 39.8% (P = 0.007)
- Breathing without assistance increases by the 28th day by 65.7% vs 55.0%
- The number of ventilator free days increases by 12 ± 11 vs 10 ± 11. days (P = 0.007)
ARDS is a life-threatening condition for which the mortality was quoted in this study to be approximately 40 to 50 percent. (To be blunt, any study that uses death as its primary outcome is looking at a very ill cohort.)
Much has been learned about the pathophysiology of ARDS, but very little headway has been made in the treatment of it. The authors of this study looked at adjusting ventilatory tidal volume and plateau pressures for treatment for ARDS. The authors also measured plasma interleukin-6 in the first 204 of 234 patients as a measure of lung inflammation. The results were significantly in favor of the lower tidal volume group.
This was a prospective, randomized controlled study that assorted 861 patients into two groups. Patients were randomly selected to be treated with tradition ventilation treatments, initial tidal volumes of 12 ml per kilogram of predicted body weight and a plateau pressure of 50 cm of water or less, versus lower tidal volumes of 6 ml per kilogram of predicted body weight and a plateau pressure of 30 cm of water or less.