Dr. Joel Pedersen will be joining us for the first Superfund Seminar Series of the 2016-2017 season. Friday, September 9, 2016, Dr. Pedersen, professor of environmental organic and biophysical chemistry; behavior of organic chemicals, macromolecules and nanoparticles in terrestrial and aquatic environments at the University of Wisconsin-Madison, will lecture on Insights into Nanoparticle Interaction with Cell Surfaces from Model Systems.
Dr. Pedersen’s talk will focus on how cell surfaces (cytoplasmic membranes, bacterial cell envelopes) serve as initial points of contact between cells and nanomaterials that have been either intentionally or inadvertently released into the environment. Mechanistic understanding of nanomaterial interaction with cell surfaces requires consideration of bnanoparticle surface chemistry and the chemical composition, physical properties, and lateral organization of cell surfaces. We have developed models for cell surfaces containing key molecular components to study in detail the processes and cell surface properties perturbed by interaction with specific ligand-nanoparticle combinations. We complement our experimental investigations with computational studies to provide further insight into processes at the nano-bio interface. We have found that phase-segregated domains, glycolipid species, and membrane proteins influence nanoparticle interaction with model cell surfaces. We will discuss our recent work demonstrating the importance of different lipid and non-lipid components of cell surfaces on their interaction with engineered nanoparticles.
The Pedersen research group focuses on environmental interfacial chemistry and studies interfacial processes affecting the behavior of nanoparticles, biomolecules, and organic molecules in terrestrial and aquatic environments.