Unfortunately, due to the winter weather, we have had to cancel this seminar.
Please join us for our next Superfund Research Program Seminar: Addressing Uncertainty and Population Variability in Risk Assessment: Challenges and Opportunities on Friday, February 10, 2017, 12:00 – 1:00, at 184 Hope Street, Barus and Holley room 190.
Dr. Weihsueh Chiu will be discussing the rapid advance of high-throughput testing and other new biological technologies has the potential to address a broad range of needs in health risk assessment. One important need is for risk assessments to quantitatively characterize uncertainty and variability, so as to provide decision-makers with a sense of the confidence in estimated risks and the extent to which susceptible individuals are protected. New and emerging tools, methods, and approaches to characterize uncertainty and variability are beginning to be incorporated into risk assessment. A common theme for all these approaches is the integration of population-based data and experimental models using probabilistic computational/statistical models. For instance, probabilistic PBPK modeling approaches provide a characterization of toxicokinetic uncertainty and variability, but have been applied in only a few cases such as the common Superfund contaminant trichloroethylene. On the other hand, approaches to address uncertainty and variability in toxicodynamics or downstream disease processes are only beginning to be explored. Additionally, a new probabilistic framework developed by the World Health Organization provides a potential means to integrate both old and new data streams together, while also providing more quantitative and transparent characterizations of risk. Taken together, these new approaches have risk management implications related to specifying the acceptable levels of uncertainty, population incidence, and magnitudes of effect in a particular risk context.
Weihsueh A. Chiu, Ph.D. is a professor in the Department of Veterinary Integrative Biosciences at the Texas A&M University College of Veterinary Medicine and Biomedical Sciences. He also has a Research Fellow appointment at the Institute for Science, Technology, and Public Policy at the Bush School of Government and Public Service. He received a bachelor’s degree in Physics from Harvard University, and earned a PhD in Physics from Princeton University as well as a Certificate in Science, Technology, and Environmental Policy from the Woodrow Wilson School of Public and International Affairs. Dr. Chiu spent the first 16 years of his career in government service, first at the U.S. Government Accountability Office, and then at the U.S. Environmental Protection Agency. Throughout his career, he has been involved in a diverse span of risk-related topics, such as defense against chemical-biological warfare agents, radioactive contamination in biosolids, human health risks from environmental chemical exposures, and the interface between science and policy. His recent research has focused on human health risk assessment, particularly with respect to toxicokinetics, mechanisms of toxicity, physiologically-based pharmacokinetic modeling, dose-response assessment, and characterizing uncertainty and variability. He has a particular interest in the development and use of Bayesian and probabilistic methods. Much of his research has used the common contaminants trichloroethylene and tetrachloroethylene as model compounds, but recently he has become involved in projects utilizing high throughput in vitro systems addressing over a hundred compound at a time. Dr. Chiu has served on a variety of expert review panels for government agencies, as well as workgroups for the World Health Organization International Agency for Research on Cancer, International Program on Chemical Safety, the Organisation for Economic Cooperation and Development, and the U.S. National Academy of Sciences.
We hope to see you there!