SNX27 Protein Placer

The SNZ27 Protein Placer (SPP) is a recently developed shot that enables humans to place the SNZ27 protein into the brains of people who have down syndrome. At around the year 2013, it was found that people diagnosed with down syndrome lacked the SNZ27 Protein; hence, they had less glutamate receptors, impairing their memory and learning. Finally, we have found a human-safe product that will enable our down syndrome patients to take a step forward in the ridding of the mutation.

The SNX27 protein works in the plasma membranes of the brain. We have been successful in creating an artificial copy of the protein which does the exact same job as the original protein: helping with the retrogade transport from the endosome to the plasma membrane. The final product will be placed in the brain by a protein filled shot. This shot is able to reach the brain because we have enabled it to only cover the central nervous system. Also, this would not have been possible without the making of another protein that will allow the SNX27 proteins to follow neurons. Therefore, after being injected to the arm, it will follow the sensory neurons to the interneurons. Then it will travel up the spinal cord and reach the brain.

This is a very “futuristic” idea. First, in order to accomplish this, we would need to create an artificial copy of the SNX27 protein. Then, we would need to make a shot that is able to hold a sufficient amount of this protein. Finally, and the most unlikely, we would need to find a way for the protein to reach the brain safely without going anywhere else. Discovering all of these things may take a long, long time.

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2 responses to “SNX27 Protein Placer”

  1. Ava Lakmazaheri says:

    Given that some synthetic proteins already exist, when do you think we will be able to successfully replicate the SNX27 protein?

  2. Carlos Aizenman says:

    Great idea. In effect this is what gene therapy aims to accomplish. For example use a virus that has the DNA for a protein you want to introduce and have it inject the DNA into the host cells so they can begin to make the protein. In your case you would need a virus that can infect brain cells but is attenuated enough not to kill them, then build a virus containing the SNX27 protein. There are various issues, for example is it ok to target any neurons, or does the virus need to infect a specific subpopulation. Once the gene is in, how will expression of SNX27 be regulated, etc.

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